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Human coronary microvascular contractile dysfunction associates with viable synthetic smooth muscle cells

Abstract:

Aims
Coronary microvascular smooth muscle cells (SMCs) respond to luminal pressure by developing myogenic tone (MT), a process integral to the regulation of microvascular perfusion. The cellular mechanisms underlying poor myogenic reactivity in patients with heart valve disease are unknown and form the focus of this study.
Methods and results
Intramyocardial coronary micro-arteries (IMCAs) isolated from human and pig right atrial (RA) appen... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvab218

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Pharmacology
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0002-8014-2775
More by this author
Role:
Author
ORCID:
0000-0003-0458-9871
More by this author
Role:
Author
ORCID:
0000-0002-1694-2786
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular research Journal website
Volume:
118
Issue:
8
Pages:
1978–1992
Publication date:
2021-06-26
Acceptance date:
2021-06-23
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pmid:
34173824

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