Functional analysis of cancer/testis antigens in human cancer

Thesis

The cancer/testis (CT) antigens are a family of genes that are silenced in the majority of normal human tissues, except for the testes, but are specifically re-expressed in a number of human tumours. Interestingly, their expression is frequently found in only a subpopulation of cells in malignancies, but the reasons for this heterogeneous expression pattern have not yet been investigated. Since little is known about the regulation and the biological significance of the CT antigens, it is n...

Expand abstract

Authors: Pagotto, A

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: heterogeneity of expression; apoptosis; CT antigens; cancer; post-translational regulation
• Subjects: Tumours; Oncology; Biochemistry; Cell Biology (see also Plant sciences); Biology (medical sciences); Tumour pathology