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Journal article

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

Abstract:

Background: Activated type 1 IGF receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionising radiation. Here, we tested the clinical relevance of these findings.

Methods: We assessed associations between IGF-1R and clinical outcomes by immunohistochemistry in diagnostic biopsies of 136 men treated with 55-70 Gy external beam radiotherapy for ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/bjc.2017.337

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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Publisher:
Cancer Research UK Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
117
Issue:
2017
Pages:
1600-1606
Publication date:
2017-10-03
Acceptance date:
2017-08-06
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Source identifiers:
724711
Pubs id:
pubs:724711
UUID:
uuid:24b3d799-dd13-4208-8bfc-76458a687e09
Local pid:
pubs:724711
Deposit date:
2017-08-31

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