Thesis
Towards understanding of unconventional kinetochores in kinetoplastids
- Abstract:
-
The kinetochore is the macromolecular protein machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids, an evolutionarily divergent group of eukaryotes, possess a unique set of kinetochore proteins (KKT1—20, 22—25 and KKIP1—12) that lack significant similarity to known kinetochore components in other eukaryotes.
To date, KKT4 is the only component of kinetoplastid kinetochores shown to have microtubule-binding activities. However, the KK...
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Authors
Contributors
+ Akiyoshi, B
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0001-6010-394X
+ Redfield, C
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0001-7297-7708
+ Musacchio, A
Institution:
Max Planck Institute of Molecular Physiology
Sub department:
Biochemistry
Role:
Examiner
+ Higgins, M
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Oxford college:
Merton College
Role:
Examiner
Funding
+ Boehringer Ingelheim Fonds
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100001645
Funding agency for:
Ludzia, P
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-10-05
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Terms of use
- Copyright holder:
- Ludzia, P
- Copyright date:
- 2021
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