Thesis icon

Thesis

Towards understanding of unconventional kinetochores in kinetoplastids

Abstract:

The kinetochore is the macromolecular protein machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids, an evolutionarily divergent group of eukaryotes, possess a unique set of kinetochore proteins (KKT1—20, 22—25 and KKIP1—12) that lack significant similarity to known kinetochore components in other eukaryotes.

To date, KKT4 is the only component of kinetoplastid kinetochores shown to have microtubule-binding activities. However, the KK...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Research group:
Bungo Akiyoshi
Oxford college:
Hertford College
Role:
Author
ORCID:
0000-0002-1678-6875

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0001-6010-394X
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0001-7297-7708
Institution:
Max Planck Institute of Molecular Physiology
Sub department:
Biochemistry
Role:
Examiner
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Oxford college:
Merton College
Role:
Examiner
More from this funder
Programme:
Boehringer Ingelheim Fonds PhD Fellowship
Funding agency for:
Ludzia, P
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-10-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP