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Journal article

Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair

Abstract:

Heterogeneity of stem cells or their niches is likely to influence tissue regeneration. Here we reveal stem/precursor cell diversity during wound repair in larval zebrafish somitic body muscle using time-lapse 3D confocal microscopy on reporter lines. Skeletal muscle with incision wounds rapidly regenerates both slow and fast muscle fibre types. A swift immune response is followed by an increase in cells at the wound site, many of which express the muscle stem cell marker Pax7. Pax7(+) cells ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dmm.022251

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Funding agency for:
Koth, J
Grant:
PG/14/ 39/30865 to R. K. Patient
More from this funder
Funding agency for:
Koth, J
Grant:
PG/14/ 39/30865 to R. K. Patient
More from this funder
Funding agency for:
Koth, J
Grant:
PG/14/ 39/30865 to R. K. Patient
Publisher:
Company of Biologists Publisher's website
Journal:
Disease Models and Mechanisms Journal website
Volume:
9
Issue:
6
Pages:
671-684
Publication date:
2016-05-27
Acceptance date:
2016-04-27
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
Pmid:
27149989
Source identifiers:
628776
Language:
English
Keywords:
Pubs id:
pubs:628776
UUID:
uuid:2530ee22-3007-4da9-82da-6d73f22c3a51
Local pid:
pubs:628776
Deposit date:
2017-06-13

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