Journal article
Human CD8+ T cells exhibit a shared antigen threshold for different effector responses
- Abstract:
-
Abstract T cells recognising cognate pMHC antigens become activated to elicit a myriad of cellular responses, such as target cell killing and the secretion of different cytokines, that collectively contribute to adaptive immunity. These effector responses have been hypothesised to exhibit different antigen dose and affinity thresholds, suggesting that pathogen-specific information may be encoded within the nature of the antigen. Here, using systematic experiments in a reductionist system, whe...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 205
- Issue:
- 4
- Article number:
- ji2000525
- Publication date:
- 2020-08-17
- Acceptance date:
- 2020-07-21
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
Item Description
- Language:
- eng
- Keywords:
- Pubs id:
-
1103400
- Local pid:
- pubs:1103400
- Deposit date:
- 2020-07-24
Terms of use
- Copyright holder:
- Abu_Shah et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Authors This article is distributed under the terms of the CC BY 4.0 Unported license.
- Licence:
- CC Attribution (CC BY)
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