Journal article
Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina
- Abstract:
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There is much debate on the adeno-associated virus (AAV) serotype that best targets specific retinal cell types and the route of surgical delivery — intravitreal or subretinal. This study compared three of the most efficacious AAV vectors known to date in a mouse model of retinal degeneration (rd1 mouse) and macaque and human retinal explants. GFP driven by a ubiquitous promoter was packaged into three AAV capsids: AAV2/8(Y733F), AAV2/2(quad Y-F) and AAV2/2(7m8). Overall AAV2/2(7m8) transduce...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 4.8MB)
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- Publisher copy:
- 10.1038/gt.2017.85
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Authors
Funding
Woolf Fisher Trust
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Wellcome Trust.
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Biotechnology and Biological Sciences Research Council
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National Institute for Health Research
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Medical Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Gene Therapy Journal website
- Volume:
- 24
- Pages:
- 787–800
- Publication date:
- 2017-11-01
- Acceptance date:
- 2017-08-23
- DOI:
- EISSN:
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1476-5462
- ISSN:
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0969-7128
Item Description
- Pubs id:
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pubs:724038
- UUID:
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uuid:25a9b246-4079-469f-a7ac-01cd55a40f1c
- Local pid:
- pubs:724038
- Deposit date:
- 2017-08-24
Terms of use
- Copyright holder:
- Hickey et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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