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[Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)]

Abstract:

We have investigated seven cases of large cell lymphomas (LCL) developing simultaneously or metachronously to nodular lymphocyte-predominant Hodgkin's disease (nodular paragranuloma, NP) for the presence of EBV and the chromosomal translocation t(14;18) by use of the polymerase chain reaction (PCR). The expression of the bcl-2 oncogene product in these cases and in five cases of progressive transformation of germinal centres as a potential precursor of NP was detected immunohistochemically wi...

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Journal:
Verhandlungen der Deutschen Gesellschaft fur Pathologie
Volume:
76
Pages:
169-172
Publication date:
1992-01-01
ISSN:
0070-4113
Source identifiers:
486743

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