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Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.

Abstract:

We have previously shown that cells lacking the MHC encoded proteasome subunits LMP2 and LMP7 have a severe defect in the generation of the HLA-A2 restricted influenza Matrix epitope 58-66. We have now extended this observation to other viral epitopes and demonstrated that the antigen presentation block can be restored by transfecting LMP7. We also show that the LMP7 dependent presentation of the Matrix epitope 58-66 can be overcome by expressing fragments of the influenza Matrix, up to 100 a...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
FASEB JOURNAL
Volume:
12
Issue:
5
Pages:
A1087-A1087
Publication date:
1998-03-20
ISSN:
0892-6638
Source identifiers:
96042
Language:
English
Pubs id:
pubs:96042
UUID:
uuid:25fa60ec-a6d8-4ab6-a74c-50f98125fd71
Local pid:
pubs:96042
Deposit date:
2012-12-19

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