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Journal article

Changes in presynaptic gene expression during homeostatic compensation at a central synapse

Abstract:

Homeostatic matching of pre- and postsynaptic function has been observed in many species and neural structures, but whether transcriptional changes contribute to this form of trans-synaptic coordination remains unknown. To identify genes whose expression is altered in presynaptic neurons as a result of perturbing postsynaptic excitability, we applied a transcriptomics-friendly, temperature-inducible Kir2.1-based activity clamp at the first synaptic relay of the Drosophila olfactory system, a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/jneurosci.2979-20.2021

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Magdalen College
Role:
Author
Gatsby Charitable Foundation More from this funder
Wellcome Trust More from this funder
Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
41
Issue:
14
Pages:
3054-3067
Publication date:
2021-02-19
Acceptance date:
2021-01-28
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
33608385
Language:
English
Keywords:
Pubs id:
1165734
Local pid:
pubs:1165734
Deposit date:
2022-02-25

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