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An expanded genome-wide association study of type 2 diabetes in Europeans

Abstract:

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 × 10−8...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db16-1253

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
66
Issue:
11
Pages:
2888-2902
Publication date:
2017-05-31
Acceptance date:
2017-05-20
DOI:
ISSN:
1939-327X
Source identifiers:
700432
Language:
English
Pubs id:
pubs:700432
UUID:
uuid:262a395b-bb6a-4cfe-8803-c8e07dd73854
Local pid:
pubs:700432
Deposit date:
2017-06-24

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