Thesis
Analyses of functional sequence in mammalian and avian genomes
- Abstract:
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The first draft sequence of the human genome was published over a decade ago, yet interpreting the functional importance of nucleotides in genomes is still an ongoing challenge. I took a comparative genomic approach to identify functional sequence using signatures of natural selection in DNA sequences. Mutations that are purged or propagated by selection mark sequences of significance for biological fitness. I developed and refined methods for estimating the quantity of sequence constraine...
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Authors
Contributors
+ Ponting, C
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:27e0ac20-eb27-423c-9493-a8a1c6cc57b8
- Local pid:
- ora:8469
- Deposit date:
- 2014-05-21
Terms of use
- Copyright holder:
- Chris M. D. Rands
- Copyright date:
- 2014
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