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Thesis

Analyses of functional sequence in mammalian and avian genomes

Abstract:

The first draft sequence of the human genome was published over a decade ago, yet interpreting the functional importance of nucleotides in genomes is still an ongoing challenge. I took a comparative genomic approach to identify functional sequence using signatures of natural selection in DNA sequences. Mutations that are purged or propagated by selection mark sequences of significance for biological fitness. I developed and refined methods for estimating the quantity of sequence constraine...

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Institution:
University of Oxford
Division:
MSD
Research group:
Chris Ponting's research group, MRC Functional Genomics Unit
Oxford college:
Hertford College
Role:
Author
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Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:27e0ac20-eb27-423c-9493-a8a1c6cc57b8
Local pid:
ora:8469
Deposit date:
2014-05-21

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