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Contribution of ROB-1 and PBP3 mutations to the resistance phenotype of a β-lactamase-positive amoxicillin/clavulanic acid-resistant Haemophilus influenzae carrying plasmid pB1000 in Italy.

Abstract:

OBJECTIVES: plasmid pB1000 bearing bla(ROB-1) is responsible for high-level β-lactam resistance in Haemophilus influenzae as well as in Pasteurella multocida and Haemophilus parasuis isolates from Spain. Here, we explore the presence of ROB-1 in Italy and investigate the relative contribution of penicillin-binding protein 3 (PBP3) mutations and ROB-1 to the β-lactam resistance phenotype in H. influenzae. METHODS: the collection of the Italian Reference Laboratory of H. influenzae was investi...

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Publisher copy:
10.1093/jac/dkq392

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Journal:
Journal of antimicrobial chemotherapy
Volume:
66
Issue:
1
Pages:
96-99
Publication date:
2011-01-01
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Source identifiers:
386890

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