Thesis
Re-engineering bacterial two-component signalling systems
- Abstract:
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Bacteria use Two Component Systems (TCS) to sense and respond to changes in their external environment. TCS are used to navigate to nutrients or away from toxins (chemotaxis) and to adapt to changes in osmolarity (osomosensing). TCS are composed of a histidine protein kinase (HPK) which trans-autophosphorylates in response to environmental change, transferring the phosphoryl group to a cognate response regulator (RR). Phosphorylated RRs modulate an output response such as protein-protein i...
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Authors
Contributors
+ Wadhams, G
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Armitage, J
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2865c02d-c208-45fa-8108-d8ced9486c19
- Local pid:
- ora:8931
- Deposit date:
- 2014-09-11
Terms of use
- Copyright holder:
- Blades, G
- Copyright date:
- 2014
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