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Thesis

Exploring the substrate scope of histone demethylases

Abstract:

Post-translational modifications of histones play key roles in regulation of eukaryotic transcription and in epigenetics. Lysine methylation of histones is a dynamic balance between activity of methyl transferases and demethylases (KDMs). Fe(II) 2-oxoglutarate (2OG)-dependent Jumonji C (JmjC)-KDMs are current targets for medical chemistry. Defining the extent and role of their substrates is important from a translational perspective and is of basic scientific interest.

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Research group:
Schofield and Kawamura groups
Oxford college:
Hertford College
Role:
Author
ORCID:
https://orcid.org/0000-0002-2723-6895

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Hertford College
Role:
Supervisor
ORCID:
0000-0002-0290-6565
Institution:
University of Oxford, Newcastle University
Role:
Supervisor
More from this funder
Funding agency for:
Bonnici, J
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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