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Journal article

Potent tetrahydroquinolone eliminates apicomplexan parasites

Abstract:

Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochrome b inhibitors, JAG21 has improved solubility and ADMET properties, without need for pro-drug. JAG21 significantly reduces Toxoplasma gondii tachyzoites and encysted bradyzoites in vitro, and in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcimb.2020.00203

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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular and Infection Microbiology Journal website
Volume:
10
Publication date:
2020-06-09
Acceptance date:
2020-04-16
DOI:
EISSN:
2235-2988
Keywords:
Pubs id:
1115195
Local pid:
pubs:1115195
Deposit date:
2020-06-30

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