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Thesis

Structure-aware tools for the development of therapeutic antibodies from natural immunoglobulins

Abstract:

In this thesis, we establish the foundations for structure-based antibody drug discovery from natural immunoglobulin sequences. This is achieved through two novel software packages: ‘Repertoire Structural Profiling’ (RSP), as a means of generating structurally-diverse virtual screening libraries, and the ‘Therapeutic Antibody Profiler’ (TAP), for rapid structure-aware developability assessment of candidates in early-stage antibody drug discovery. Our approaches are orthogonal to existing work...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Oxford Protein Informatics Group
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-5663-5297

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Oxford Protein Informatics Group
Oxford college:
St Anne's College
Role:
Supervisor
ORCID:
0000-0003-1388-2252
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Research group:
Research Informatics Group
Role:
Examiner
ORCID:
0000-0002-1937-4091
Institution:
University of Oslo
Role:
Examiner
ORCID:
0000-0003-2622-5032
More from this funder
Programme:
EPSRC and MRC Centre for Doctoral Training in Systems Approaches to Biomedical Science
Grant:
EP/L016044/1
More from this funder
Programme:
EPSRC and MRC Centre for Doctoral Training in Systems Approaches to Biomedical Science
Grant:
EP/L016044/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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