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Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

Abstract:

Translocator protein (TSPO) expression is increased in activated glia, and has been used as a marker of neuroinflammation in PET imaging. However, the extent to which TSPO upregulation reflects a pro‐ or anti‐inflammatory phenotype remains unclear. Our aim was to determine whether TSPO upregulation in astrocytes and microglia/macrophages is limited to a specific inflammatory phenotype. TSPO upregulation was assessed by flow cytometry in cultured astrocytes, microglia, and macrophages stimu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/glia.23716

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Oxford Institute for Radiation Oncology
Role:
Author
ORCID:
0000-0002-7764-5574
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Oxford Institute for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Oxford Institute for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Expand authors...
Publisher:
Wiley Publisher's website
Journal:
Glia Journal website
Volume:
68
Issue:
2
Pages:
280-297
Publication date:
2019-09-03
Acceptance date:
2019-08-20
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
Source identifiers:
1049168
Language:
English
Keywords:
Pubs id:
pubs:1049168
UUID:
uuid:29cfee84-b963-46d2-96b0-5de7e451a33a
Local pid:
pubs:1049168
Deposit date:
2019-09-04

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