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Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

Abstract:

The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an important role in preserving genomic stability, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.092544

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
285
Issue:
14
Pages:
10362-10369
Publication date:
2010-04-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
101145

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