Journal article
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.
- Abstract:
-
The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an important role in preserving genomic stability, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m109.092544
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 285
- Issue:
- 14
- Pages:
- 10362-10369
- Publication date:
- 2010-04-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
101145
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:101145
- UUID:
-
uuid:2a97d37f-f5f6-4ffd-a668-b321b2e20d86
- Local pid:
- pubs:101145
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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