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Journal article

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

Abstract:

The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI32460

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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G0501257/Medical Research Council More from this funder
G0600520/Medical Research Council More from this funder
MC_U137884180/Medical Research Council More from this funder
/Wellcome Trust More from this funder
/Medical Research Council More from this funder
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
118
Issue:
10
Pages:
3478-3490
Publication date:
2008-10-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
18802496
Source identifiers:
31316

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