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Identification of myocardial disarray in patients with hypertrophic cardiomyopathy and ventricular arrhythmias

Abstract:

Background: Myocardial disarray is a likely focus for fatal arrhythmia in hypertrophic cardiomyopathy (HCM). This microstructural abnormality can be inferred by mapping the preferential diffusion of water along cardiac muscle fibers using diffusion tensor cardiac magnetic resonance (DT-CMR) imaging. Fractional anisotropy (FA) quantifies directionality of diffusion in 3 dimensions. The authors hypothesized that FA would be reduced in HCM due to disarray and fibrosis that ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jacc.2019.02.065

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Oxford college:
Exeter College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of the American College of Cardiology Journal website
Volume:
73
Issue:
20
Pages:
2493-2502
Publication date:
2019-05-20
Acceptance date:
2019-02-26
DOI:
ISSN:
1558-3597
Source identifiers:
976565
Keywords:
Pubs id:
pubs:976565
UUID:
uuid:2abcb92c-05df-4a5e-91ed-ae5d7ceea7b0
Local pid:
pubs:976565
Deposit date:
2019-02-26

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