Journal article
Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
- Abstract:
-
Inhibition by intracellular H(+) (pH gating) and activation by phosphoinositides such as PIP(2) (PIP(2)-gating) are key regulatory mechanisms in the physiology of inwardly-rectifying potassium (Kir) channels. Our recent findings suggest that PIP(2) gating and pH gating are controlled by an intra-subunit H-bond at the helix-bundle crossing between a lysine in TM1 and a backbone carbonyl group in TM2. This interaction only occurs in the closed state and channel opening requires this H-bond to b...
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- Publication status:
- Published
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- Publisher copy:
- 10.4161/chan.5176
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Authors
Bibliographic Details
- Journal:
- Channels (Austin, Tex.)
- Volume:
- 1
- Issue:
- 5
- Pages:
- 327-330
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1933-6969
- ISSN:
-
1933-6950
- Source identifiers:
-
20895
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:20895
- UUID:
-
uuid:2af95dbf-f329-485c-a574-67d89fe12c13
- Local pid:
- pubs:20895
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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