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Journal article

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

Abstract:

Inhibition by intracellular H(+) (pH gating) and activation by phosphoinositides such as PIP(2) (PIP(2)-gating) are key regulatory mechanisms in the physiology of inwardly-rectifying potassium (Kir) channels. Our recent findings suggest that PIP(2) gating and pH gating are controlled by an intra-subunit H-bond at the helix-bundle crossing between a lysine in TM1 and a backbone carbonyl group in TM2. This interaction only occurs in the closed state and channel opening requires this H-bond to b...

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Publication status:
Published

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Publisher copy:
10.4161/chan.5176

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Journal:
Channels (Austin, Tex.)
Volume:
1
Issue:
5
Pages:
327-330
Publication date:
2007-01-01
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
Source identifiers:
20895

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