Journal article icon

Journal article

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations

Abstract:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neuron-like cells. Mutations in the RNA- and DNA-binding proteins, fused in sarcoma (FUS) and transactive response DNA-binding protein 43 kDa (TDP-43), are responsible for 5-10% of familial and 1% of sporadic ALS cases. Importantly, aggregation of misfolded FUS or TDP-43 is also characteristic of several neurodegenerative disorders in addition to ALS, including frontotemporal lobar degenerati...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/hmg/ddv104

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Liu, K
More from this funder
Funding agency for:
Liu, K
More from this funder
Funding agency for:
Oliver, P
Grant:
PAROSIN
Medical Research Council More from this funder
Expand funders...
Publisher:
Oxford University Press Publisher's website
Journal:
Human molecular genetics Journal website
Volume:
24
Issue:
12
Pages:
3529-3544
Publication date:
2015-03-19
Acceptance date:
2015-03-16
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
514830
Language:
English
Pubs id:
pubs:514830
UUID:
uuid:2b031ea4-9680-49bc-9cb0-7adc518e91cc
Local pid:
pubs:514830
Deposit date:
2016-02-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP