Journal article
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
- Abstract:
-
Serial femtosecond crystallography has opened up many new opportunities in structural biology. In recent years, several approaches employing light-inducible systems have emerged to enable time-resolved experiments that reveal protein dynamics at high atomic and temporal resolutions. However, very few enzymes are light-dependent, whereas macromolecules requiring ligand diffusion into an active site are ubiquitous. In this work we present a drop-on-drop sample delivery system that enables the s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
NIGMS NIH HHS
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 12
- Issue:
- 1
- Article number:
- 4461
- Publication date:
- 2021-07-22
- Acceptance date:
- 2021-07-01
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
34294694
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1188093
- Local pid:
- pubs:1188093
- Deposit date:
- 2021-09-17
Terms of use
- Copyright holder:
- Butryn et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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