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Thesis

Refocusing antibody responses by chemical modification of vaccine antigens

Abstract:

The envelope glycoprotein (Env) of Human Immunodeficiency Virus 1 (HIV-1) has developed several immune-evasion mechanisms to avoid the induction of neutralising antibodies, including immunodominant non-neutralising epitopes, conformational flexibility of conserved epitopes, and spontaneous subunit dissociation, thus impeding vaccine development. Here, chemical modification of Env-based vaccine antigens is explored to overcome these obstacles.

Firstly, covalent fixation of Env by che...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Sattentau Lab
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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