Refocusing antibody responses by chemical modification of vaccine antigens
The envelope glycoprotein (Env) of Human Immunodeficiency Virus 1 (HIV-1) has developed several immune-evasion mechanisms to avoid the induction of neutralising antibodies, including immunodominant non-neutralising epitopes, conformational flexibility of conserved epitopes, and spontaneous subunit dissociation, thus impeding vaccine development. Here, chemical modification of Env-based vaccine antigens is explored to overcome these obstacles.
Firstly, covalent fixation of Env by che...Expand abstract
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- Oxford University, UK
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- Schiffner, T
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