Journal article icon

Journal article

Influenza virus mounts a two-pronged attack on host RNA polymerase II transcription

Abstract:

Influenza virus intimately associates with host RNA polymerase II (Pol II) and mRNA processing machinery. Here, we use mammalian native elongating transcript sequencing (mNET-seq) to examine Pol II behavior during viral infection. We show that influenza virus executes a two-pronged attack on host transcription. First, viral infection causes decreased Pol II gene occupancy downstream of transcription start sites. Second, virus-induced cellular stress leads to a catastrophic failure of Pol II t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2018.04.047

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Proudfoot, N
Grant:
Investigator award 107928/Z/15/Z
More from this funder
Funding agency for:
Proudfoot, N
Grant:
Investigator award 107928/Z/15/Z
More from this funder
Funding agency for:
Murphy, S
Grant:
Investigator award WT106134A
More from this funder
Funding agency for:
Fodor, E
Grant:
MR/K000241/1
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
7
Pages:
2119-2129.e3
Publication date:
2018-05-15
Acceptance date:
2018-04-20
DOI:
ISSN:
2211-1247
Source identifiers:
843909
Keywords:
Pubs id:
pubs:843909
UUID:
uuid:2b625075-822d-450b-a18a-c689c4626a3c
Local pid:
pubs:843909
Deposit date:
2018-04-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP