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Practical approaches for detecting selection in microbial genomes

Abstract:

Microbial genome evolution is shaped by a variety of selective pressures. Understanding how these processes occur can help to address important problems in microbiology by explaining observed differences in phenotypes, including virulence and resistance to antibiotics. Greater access to whole-genome sequencing provides microbiologists with the opportunity to perform large-scale analyses of selection in novel settings, such as within individual hosts. This tutorial aims to guide researchers th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1004739

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Funding agency for:
Wilson, D
Grant:
Sir Henry Dale Fellow
101237/Z/13/Z
More from this funder
Funding agency for:
Wilson, D
Grant:
Sir Henry Dale Fellow
101237/Z/13/Z
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
12
Issue:
2
Article number:
e1004739
Publication date:
2016-01-01
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Source identifiers:
606103
Language:
English
Pubs id:
pubs:606103
UUID:
uuid:2bc4fb2d-df5f-498c-9926-1af7130b957e
Local pid:
pubs:606103
Deposit date:
2016-02-29

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