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Journal article

Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks.

Abstract:

Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson's disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2-8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta ac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.21481

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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More from this funder
Funding agency for:
Herz, D
Grant:
655605
More from this funder
Funding agency for:
Brown, P
Grant:
MC_UU_12024/1
Parkinson Appeal UK More from this funder
Monument Trust More from this funder
Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
6
Pages:
e21481
Publication date:
2017-01-01
Acceptance date:
2017-01-15
DOI:
ISSN:
2050-084X
Source identifiers:
675244
Language:
English
Keywords:
Pubs id:
pubs:675244
UUID:
uuid:2bd2e480-10e9-471e-9682-28fc6fffa16d
Local pid:
pubs:675244
Deposit date:
2017-03-13

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