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Cardiac energetics in patients with aortic stenosis and preserved versus reduced ejection fraction

Abstract:

Background: Why some but not all patients with severe AS (SevAS) develop otherwise unexplained reduced systolic function is unclear. We investigate the hypothesis that reduced creatine kinase (CK) capacity and/or flux is associated with this transition.

Methods: 102 participants were recruited to five groups: moderate AS (ModAS, n=13), severe AS, LVEF ≥55% (SevAS-pEF, n=37), severe AS, LVEF<55% (SevAS-rEF, n=15), healthy volunteers w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circulationaha.119.043450

Authors


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Role:
Author
ORCID:
0000-0002-1793-3128
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-7159-7025
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Circulation Journal website
Volume:
141
Issue:
24
Pages:
1971–1985
Publication date:
2020-05-22
Acceptance date:
2020-04-16
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
1106048
Local pid:
pubs:1106048
Deposit date:
2020-05-22

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