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The mechanisms by which the ketone body D-β-Hydroxybutyrate may improve the multiple cellular pathologies of Parkinson's disease

Abstract:

Parkinson's disease, a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, is strongly associated with the death of dopaminergic neurons in the brain's substantia nigra. Although dopamine replacement therapy temporarily helps patients manage their motor symptoms, this current standard of care fails to address the underlying network of pathologies that contribute to the persistent death of dopaminergic neurons. Thus, new treatment approaches are needed that ad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fnut.2019.00063

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0002-3237-7553
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Nutrition Journal website
Volume:
6
Article number:
63
Publication date:
2019-05-14
Acceptance date:
2019-04-23
DOI:
EISSN:
2296-861X
Pmid:
31139630
Source identifiers:
1004636
Language:
English
Keywords:
Pubs id:
pubs:1004636
UUID:
uuid:2c228b12-84f4-4ecc-bac3-5dee910a152a
Local pid:
pubs:1004636
Deposit date:
2019-07-10

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