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Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell‐mediated anti‐tumour immunity in a murine mammary breast cancer model

Abstract:

Both invariant natural killer T (NK T) cells and CD4(+)CD25(+) T regulatory cells (T(regs)) regulate the immune system to maintain homeostasis. In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. By contrast, T(regs) intrinsically suppress antigen-specific immune responses and are often found to be elevated in tumour patients. In this study, we have shown that T(regs) regulate NK T cell function negatively i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0002-4077-7995
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Mary Kinross Charitable Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
Clinical and Experimental Immunology Journal website
Volume:
159
Issue:
1
Pages:
93-99
Publication date:
2009-09-02
Acceptance date:
2009-08-24
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Pmid:
19817769
Source identifiers:
17137

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