Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell‐mediated anti‐tumour immunity in a murine mammary breast cancer model

Journal article

Both invariant natural killer T (NK T) cells and CD4(+)CD25(+) T regulatory cells (T(regs)) regulate the immune system to maintain homeostasis. In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. By contrast, T(regs) intrinsically suppress antigen-specific immune responses and are often found to be elevated in tumour patients. In this study, we have shown that T(regs) regulate NK T cell function negatively i...

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Authors: Hong, H; Gu, Y; Zhang, H; Simon, A; Chen, X

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley Publisher's website
• Journal: Clinical and Experimental Immunology Journal website
• Volume: 159
• Issue: 1
• Pages: 93-99
• Publication date: 2009-09-02
• Acceptance date: 2009-08-24
• DOI: 10.1111/j.1365-2249.2009.04018.x
• EISSN: 1365-2249
• ISSN: 0009-9104
• Pmid: 19817769
• Language: English
• Keywords: Interferon-gamma; Galactosylceramides; Lymphocyte Depletion; Antibodies, Monoclonal; Female; Journal Article; Mice, Inbred C57BL; Mice, Inbred BALB C; Mice; Mammary Neoplasms, Experimental; T-Lymphocytes, Regulatory; Lymphocyte Activation; Dendritic Cells; Natural Killer T-Cells; Interleukin-2 Receptor alpha Subunit; Immunity, Cellular; Animals; SBTMR; Disease Models, Animal; Survival Rate; Research Support, Non-U.S. Gov't; Lung Neoplasms