Thesis
Therapeutic targeting of PRMT5 and mutant ACVR1 in paediatric glioma
- Abstract:
-
Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal paediatric brainstem tumour with a median overall survival of 9-11 months. The unique genetic, anatomical and developmental identity of the tumour means that there are currently no effective chemotherapies or targeted therapies. This thesis aimed to identify and characterise novel targets for the treatment of DIPG. Potential therapeutic opportunities arise from the frequent mutations found in histone H3 (H3K27M) and kinase ACVR1 f...
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Authors
Contributors
+ Bullock, A
Institution:
University of Oxford
Role:
Supervisor
ORCID:
0000-0001-6757-0436
+ Farnie, G
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Supervisor
ORCID:
0000-0002-1407-2529
Funding
+ Oxford-The Simcox Family Scholarship
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Programme:
Oxford-The Simcox Family Scholarship
Funding agency for:
Brown, EJ
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-04-12
Related Items
Terms of use
- Copyright holder:
- Brown, EJ
- Copyright date:
- 2021
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