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Journal article

B and CTL responses to the ALK protein in patients with ALK-positive ALCL.

Abstract:

Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) has a good prognosis compared to ALK-negative ALCL, possibly as a result of the immune recognition of the ALK proteins. The aim of our study was to investigate the presence of both a B and cytotoxic T cell (CTL) response to ALK in ALK-positive ALCL. We confirmed the presence of an antibody response to ALK in all 9 ALK-positive ALCL patients investigated. An ELISpot assay was used to detect a gamma-interferon (IFN)...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.21410

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
International journal of cancer. Journal international du cancer
Volume:
118
Issue:
3
Pages:
688-695
Publication date:
2006-02-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
96025

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