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Journal article

Cytoskeletal actin patterns shape mast cell activation

Abstract:

Activation of immune cells relies on a dynamic actin cytoskeleton. Despite detailed knowledge of molecular actin assembly, the exact processes governing actin organization during activation remain elusive. Using advanced microscopy, we here show that Rat Basophilic Leukemia (RBL) cells, a model mast cell line, employ an orchestrated series of reorganization events within the cortical actin network during activation. In response to IgE antigen-stimulation of FCε receptors (FCεR) at the RBL cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-019-0322-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Institute of Molecular Medicine
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Communications Biology Journal website
Volume:
2
Article number:
93
Publication date:
2019-03-07
Acceptance date:
2019-01-22
DOI:
EISSN:
2399-3642
Pubs id:
pubs:965723
UUID:
uuid:2d1c6aa2-2cb9-469c-9c96-0d781dfd562a
Local pid:
pubs:965723
Deposit date:
2019-01-23

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