Journal article icon

Journal article

Chemical instability and promiscuity of arylmethylidenepyrazolinone-based MDMX inhibitors

Abstract:

Targeting the protein-protein interaction between p53 and MDM2/MDMX (MDM4) represents an attractive anticancer strategy for the treatment of p53-competent tumors. Several selective and potent MDM2 inhibitors have been developed and entered the clinic; however, the repertoire of MDMX antagonists is still limited. The arylmethylidenepyrazolinone SJ-172550 has been reported as a selective MDMX antagonist; yet, uncertainties about its mechanism of action have raised doubts about its use as a chem...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1021/acschembio.8b00665

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Genomics Consortium
Oxford college:
New College
Role:
Author
ORCID:
0000-0001-9151-4485
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-6447-354X
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-6241-0238
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-3963-0021
Expand authors...
Engineering and Physical Sciences Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Chemical Biology Journal website
Volume:
13
Issue:
10
Pages:
2849–2854
Publication date:
2018-09-14
Acceptance date:
2018-09-14
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
Pmid:
30216042
Source identifiers:
920451
Language:
English
Pubs id:
pubs:920451
UUID:
uuid:2d5ebe74-37ab-4948-86e7-2e8c28ff5244
Local pid:
pubs:920451
Deposit date:
2018-10-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP