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Thesis

Investigating the effects of IFNγ signalling on transcriptional, epigenetic and enhancer landscapes

Abstract:

IFNγ signalling can have contradictory roles in a tumour microenvironment. Predominantly, IFNγ has an anti-tumour function, activating the immune system against the cancer. However, pro-tumour activities of IFNγ have also been observed. Its choice between the two opposing outcomes appears to be context dependent and the mechanism instructing this choice isn’t well understood. One prevailing determinant comes from the IFNγ-induced upregulation of PD-L1, an immunosuppressive ligand. Binding ...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Role:
Supervisor
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Programme:
Wellcome Trust, Chromosome and Developmental Biology, Four-year PhD Studentship
Grant:
203796/Z/16/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-04-28

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