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Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels

Abstract:

Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal.
We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ~700 men without prostat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.30206

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Grant:
C18281/A19169, C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565
National Institute for Health Research More from this funder
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Grant:
FP7/2007-2013) 223175 (HEALTH-F2-2009-223175) (COGS
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Publisher:
Wiley Publisher's website
Journal:
International Journal of Cancer Journal website
Publication date:
2016-01-01
Acceptance date:
2016-04-13
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
615257
Keywords:
Pubs id:
pubs:615257
UUID:
uuid:2e14123c-b989-4d04-ad80-60a42f1b1ff2
Local pid:
pubs:615257
Deposit date:
2016-04-14

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