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Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function

Abstract:

EphA2 is a member of the receptor tyrosine kinase family. Interactions of the cytoplasmic region of EphA2 with the cell membrane are functionally important and yet remain incompletely characterized. Molecular dynamics simulations combined with biochemical studies reveal the interactions of the transmembrane, juxtamembrane (JM), and kinase domains with the membrane. We describe how the kinase domain is oriented relative to the membrane and how the JM region can modulate this interaction. We hi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.str.2018.05.003

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Funding agency for:
Seiradake, E
Grant:
MR/L018039/1
More from this funder
Funding agency for:
Jones, E
Grant:
A17721
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
26
Issue:
7
Pages:
1025-1034
Publication date:
2018-06-04
Acceptance date:
2018-05-08
DOI:
ISSN:
0969-2126
Keywords:
Pubs id:
pubs:846912
UUID:
uuid:2e1b8c10-ef98-438a-b9a7-a0243d13ac0f
Local pid:
pubs:846912
Deposit date:
2018-05-09

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