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Journal article

53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms

Abstract:

The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two decades ago. However, its direct contributions to p53-dependent cellular activities remain undefined. Here, we reveal that 53BP1 stimulates genome-wide p53-dependent gene transactivation and repression events in response to ionizing radiation (IR) and synthetic p53 activation. 53BP1-dependent p53 modulation requires both auto-oligomerizati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2016.08.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
UAS
Department:
Academic Administration Division
Sub department:
Divisional Administration
Role:
Author
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Funding agency for:
Cuella-Martin, R
Grant:
DPhil studentship
More from this funder
Funding agency for:
Snellenberg, S
Grant:
H2020-MSCA-IF-2014-656357
More from this funder
Funding agency for:
Chapman, J
Grant:
C52690/A19270
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
64
Issue:
1
Pages:
51-64
Publication date:
2016-08-18
Acceptance date:
2016-07-29
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
27546791
Source identifiers:
640406
Language:
English
Pubs id:
pubs:640406
UUID:
uuid:2e3df968-a1c8-4f26-bdcf-6e7353027c30
Local pid:
pubs:640406
Deposit date:
2016-09-07

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