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The regulatory factor ZFHX3 modifies circadian function in SCN via an AT motif-driven axis

Abstract:

We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3(Sci)), which accelerates circadian locomotor rhythms in mice. ZFHX3 regulates transcription via direct interaction with predicted AT motifs in target genes. The mutant protein has a decreased ability to activate consensus AT motifs in vitro. Using RNA sequencing, we found minimal effects on core clock genes in Zfhx3(Sci/+) SCN, whereas the expression of neuropeptides critical for SCN ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2015.06.060

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Funding agency for:
Jagannath, A
Grant:
090684/Z/09/Z
More from this funder
Funding agency for:
Jagannath, A
Grant:
090684/Z/09/Z
Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
162
Issue:
3
Pages:
607-621
Publication date:
2015-07-30
Acceptance date:
2015-06-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
535641
Language:
English
Pubs id:
pubs:535641
UUID:
uuid:2e5f2c75-28c2-46fd-ba3d-d4b8b801a7e5
Local pid:
pubs:535641
Deposit date:
2015-10-28

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