Thesis
Development of clinical biomarkers of DNA double strand breaks for cancer care
- Abstract:
-
Many anticancer therapies, including radiotherapy, act by damaging the deoxyribosenucleic acid (DNA) that is fundamental to cell function and proliferation. H2AX is a histone protein associated with DNA that is phosphorylated to produce γH2AX in response to DNA double strand breaks (DSBs), the most lethal lesions caused in cancer cells. This thesis examines the translation of γH2AX detection assays to clinical situations in order to provide biomarkers of response that might help to guide t...
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Authors
Contributors
+ Vallis, K
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2e6b2595-fbbc-4fff-80e2-bec8a4d9d15e
- Local pid:
- ora:9040
- Deposit date:
- 2014-10-07
Terms of use
- Copyright holder:
- Dr Ketan Shah
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available in ORA.
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