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Thesis

Investigation of binding preferences and identification of novel binding partners for the SH3 domains of the multifunctional adaptor protein CD2AP

Abstract:

CD2AP is a member of the CD2AP/CIN85 family of adaptors and involved in several cellular processes, such as kidney podocyte development, actin mediated membrane trafficking and T cell activation. It contains three SH3 domains whose binding properties and interaction partners remain largely unexplored.

The CD2AP SH3 interaction with the novel partner Rab5-activating GEF RIN3 was studied extensively by isothermal titration calorimetry (ITC), peptide scanning arrays, mutagenesis and X-...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
University College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:2eb39788-1916-4995-bd2c-b910d06a5a9b
Local pid:
ora:10848
Deposit date:
2015-04-09

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