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Thesis

Genetic analysis of DNA double-strand break mis-repair mechanisms using the human endogenous HPRT gene

Abstract:

DNA double strand breaks (DSBs) are the most lethal radiation-induced lesions in response to which cells employ either the error free homologous recombination (HR) repair pathway or error prone mechanisms, such as non homologous end joining (NHEJ) and microhomology- mediated end joining (MMEJ). While MMEJ is suppressed by C-NHEJ, the relationship between HR and MMEJ is less clear. In this thesis, I have exploited the human endogenous HPRT gene to develop a novel genetic tech...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Department:
Oncology
Role:
Supervisor
Department:
Imperial College London
Role:
Supervisor
Clarendon Fund More from this funder
Cancer Research UK More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:2ebfaf6f-cc69-4b1c-918b-9be2280b51ff
Deposit date:
2018-01-18

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