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WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer

Abstract:

Background Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role of the E3 ligase WSB-1 in breast cancer biology in the context of the hypoxic tumour microenvironment, particularly regarding metastatic spread. Methods In this study, WSB-1 expression was evaluated in breast cancer cell lines and patient samples. In silico analyses were use...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-018-0056-3

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Role:
Author
ORCID:
0000-0002-1837-986X
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Breast Cancer Now More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
118
Issue:
9
Pages:
1229-1237
Place of publication:
England
Publication date:
2018-03-15
Acceptance date:
2018-02-21
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
29540773

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