Journal article icon

Journal article

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

Abstract:

Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if tumours regulate non-mitochondrial oxygen consumption (NMOC) is unknown. Protein-tyrosine phosphatase-1B (PTP1B) is required for Her2/Neu-driven breast cancer (BC) in mice, although the underlying mechanism and human relevance remain unclear. We found that PTP1B-deficient HER2(+) xenografts have increased hypoxia, necrosi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/ncb3376

Authors


Expand authors...
More from this funder
Funding agency for:
Schofield, C
More from this funder
Funding agency for:
Schofield, C
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
18
Issue:
7
Pages:
803-813
Publication date:
2016-07-01
Acceptance date:
2016-05-13
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Pmid:
27323329
Source identifiers:
630911
Language:
English
Keywords:
Pubs id:
pubs:630911
UUID:
uuid:2f6fbc25-f0e8-4ca9-863b-94ef3ea6b2ec
Local pid:
pubs:630911
Deposit date:
2016-11-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP