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Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Abstract:

Foot-and-mouth disease virus (FMDV) belongs to the aphthovirus genus of the Picornaviridae, a family of small, icosahedral, non-enveloped, single-stranded RNA viruses. It is a highly infectious pathogen and is one of the biggest hindrances to the international trade of animals and animal products. FMDV capsids (which are unstable below pH6.5) release their genome into the host cell from an acidic compartment, such as that of an endosome, and in the process dissociate into pentamers. Whilst ot...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1006607

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
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Contributors

Role:
Editor
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Funding agency for:
Kotecha, A
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Funding agency for:
Ren, J
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Funding agency for:
Fry, E
Grant:
G100099
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Funding agency for:
Stuart, D
Grant:
G100099
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
13
Issue:
9
Pages:
e1006607
Publication date:
2017-09-22
Acceptance date:
2017-08-24
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
28937999
Source identifiers:
730902
Language:
English
Keywords:
Pubs id:
pubs:730902
UUID:
uuid:2fa172d9-ccbb-4342-8cc4-8024d43eb4ba
Local pid:
pubs:730902
Deposit date:
2017-10-27

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