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Estimation of Parameters in DNA Mixture Analysis

Abstract:

In Cowell et al. (2007), a Bayesian network for analysis of mixed traces of DNA was presented using gamma distributions for modelling peak sizes in the electropherogram. It was demonstrated that the analysis was sensitive to the choice of a variance factor and hence this should be adapted to any new trace analysed. In the present paper we discuss how the variance parameter can be estimated by maximum likelihood to achieve this. The unknown proportions of DNA from each contributor can similarl...

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Publication status:
Published

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Journal:
JOURNAL OF APPLIED STATISTICS
Volume:
40
Issue:
11
Pages:
2423-2436
Publication date:
2011-08-09
DOI:
EISSN:
1360-0532
ISSN:
0266-4763
Source identifiers:
184651
Language:
English
Keywords:
Pubs id:
pubs:184651
UUID:
uuid:2fb6d1ee-81b1-44ad-9193-fe48575f379d
Local pid:
pubs:184651
Deposit date:
2012-12-20

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