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IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis

Abstract:

Background Fosfomycin has the potential to be re-purposed as part of a combination therapy to treat neonatal sepsis where resistance to current standard of care (SOC) is common. Limited data exist on neonatal fosfomycin pharmacokinetics and estimates of bioavailability and CSF/plasma ratio in this vulnerable population are lacking. Objectives To generate data informing the appropriate dosing of IV and oral fosfomycin in neonates using a population pharmacokinetic analysis of plasma and CSF d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jac/dkab083

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Role:
Author
ORCID:
0000-0002-5596-8532
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Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Antimicrobial Chemotherapy Journal website
Volume:
76
Issue:
7
Pages:
1855-1864
Publication date:
2021-04-14
Acceptance date:
2021-02-20
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pmid:
33855449
Language:
English
Keywords:
Pubs id:
1185849
Local pid:
pubs:1185849
Deposit date:
2021-07-13

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