Thesis
Evolved P450 mutants as general oxidation catalysts for target synthesis via C–H activation
- Abstract:
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This thesis describes synthetic studies towards three natural product precursors: the tricyclic core of the abietane diterpenoids, a bicyclic lactone intermediate on Danishefsky’s route towards eleutherobin, and the hydrocarbon core of Taxol®. These syntheses were followed by an investigation into biocatalytic oxidation with particular focus on kinetic resolution.
Chapter 1 provides an introduction to contemporary chemical and biocatalytic C–H functionalisation for the introduction...
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Authors
Contributors
+ Robertson, J
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Brasenose College
Role:
Supervisor
ORCID:
0000-0002-6809-8265
+ Wong, L
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Oxford college:
St Hugh's College
Role:
Supervisor
ORCID:
0000-0003-4875-1092
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Moloney, JG
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-06-10
Related Items
Terms of use
- Copyright holder:
- Moloney, JG
- Copyright date:
- 2022
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