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Thesis

Evolved P450 mutants as general oxidation catalysts for target synthesis via C–H activation

Abstract:

This thesis describes synthetic studies towards three natural product precursors: the tricyclic core of the abietane diterpenoids, a bicyclic lactone intermediate on Danishefsky’s route towards eleutherobin, and the hydrocarbon core of Taxol®. These syntheses were followed by an investigation into biocatalytic oxidation with particular focus on kinetic resolution.

Chapter 1 provides an introduction to contemporary chemical and biocatalytic C–H functionalisation for the introduction...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Hertford College
Role:
Author
ORCID:
0000-0001-9843-5827

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Brasenose College
Role:
Supervisor
ORCID:
0000-0002-6809-8265
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Oxford college:
St Hugh's College
Role:
Supervisor
ORCID:
0000-0003-4875-1092
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-06-10

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