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Journal article

Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.

Abstract:

Presentation of intracellular tumor-associated Ags (TAAs) in the context of HLA class I molecules offers unique cancer-specific cell surface markers for the identification and targeting of tumor cells. For most peptide Ags, the levels of and variations in cell surface presentation remain unknown, yet these parameters are of crucial importance when considering specific TAAs as targets for anticancer therapy. Here we use a soluble TCR with picomolar affinity for the HLA-A2-restricted 157-165 ep...

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Publication status:
Published

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Journal:
Journal of Immunology
Volume:
176
Issue:
12
Pages:
7308-7316
Publication date:
2006-06-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
33494

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